Research
Deep Brain Stimulation and Non-Motor Outcomes
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We are collecting detailed non-motor outcomes from our patients undergoing DBS. This prospective, longitudinal study will clarify how DBS affects cognition, mood, anxiety, autonomic symptoms, sleep, and pain. By combining these outcomes with advanced neuroimaging methods, we will investigate how electrode location and engagement of specific brain networks may influence these symptoms.
Investigating the network effects of DBS with functional MRI
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We are one of very few centres worldwide performing simultaneous DBS and fMRI. By stimulating deep brain structures while collecting fMRI data, we can investigate the network effects of DBS in our patient population.
Cognitive Enhancement in Parkinson’s Disease
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We are interested in in developing neuromodulation therapies for cognitive enhancement in Parkinson's disease. One study is investigating the potential of theta frequency (4 - 8 Hz) DBS in the STN to enhance cognitive function in PD. The research explores how stimulation targeting specific STN networks can improve working memory by modulating connectivity to brain regions like the dorsolateral prefrontal cortex.
Whole brain computational modelling in glioma
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We are collecting detailed cognitive outcomes and advanced neuroimaging in patients undergoing surgery for low-grade glioma. By combining the multimodal advanced imaging into personalized models of whole brain network dynamics, we hope to predict cognitive outcomes following surgery.
Research Funding
We have received competitive grant funding from:​
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Vancouver Coastal Health Research Institute
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Brain Tumour Foundation of Canada
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Department of Surgery, University of British Columbia
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Parkinson Canada
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National Sciences and Engineering Research Council of Canada
If you are interested in supporting our research program please email stefan.lang@vch.ca